Henri-Baptiste Marjault

Ph.D. in biology, biophysics, and computational biology validated in the Hebrew University of Jerusalem, RWTH Aachen University and Cyprus Institute through the European Joint Doctorate (EJD) program STIMULATE, under the Marie Skłodowska-Curie Actions. With a comprehensive background in cell culture, microscopy, and protein expression during postdoctoral experience. Notable strengths include expertise in recombinant protein expression, mitochondria isolation, structural biology, and drug design. Augmented by early career involvement in international scientific diplomacy at the French embassy, demonstrating a multidisciplinary approach to scientific research.

• A combination of a cell penetrating peptide and a protein translation inhibitor kills metastatic breast cancer cells, Rowland, L., Marjault, HB., Karmi, O. et al. Cell Death Discov. 9, 325 (2023). https://doi.org/10.1038/s41420-023-01627-3
• CISD3 is required for Complex I function, mitochondrial integrity, and skeletal muscle maintenance,Henri-Baptiste Marjault, Ola Karmi, Linda Rowland, Thi Thao Nguyen, DeAna Grant, Camila Manrique-Acevedo, Rachel Nechushtai, Ron Mittler doi: https://doi.org/10.1101/2023.06.03.5 43558
• Structure-Based Screening Reveals a Ligand That Stabilizes the [2Fe-2S] Clusters of Human mitoNEET and Reduces Ovarian Cancer Cell Proliferation,Henri-Baptiste Marjault, Sohn Yang-Sung, Ke Zuo, Paolo Carloni, Ron Mittler, and Rachel Nechushtai* J. Phys. Chem. B 2022, 126, 46, 9559–9565
• A peptide-derived strategy for specifically targeting the mitochondria and ER of cancer cells: a new approach in fighting cancer, Chem. Sci., 2022, Yang Sung Sohn, Anat losub-Amir, Alfredo E. Cardenas, Ola Karmi, Merav Darash Yahana, Tal Gruman, Linda Rowland, Henri-Baptiste Marjault, Lauren J. Webb, Ron Mittler, Ron Elber, Assaf Friedler, Rachel Nechushtai, https://doi.org/10.1039/D2SC01934E
• An antidiabetic drug targets NEET (CISD) proteins through destabilization of their [2Fe-2S] clusters, Communications biology, 5, 1, 19, 2022, Marjault, H. B., Karmi, O., Zuo, K., Michaeli, D., Eisenberg-Domovich, Y., Rossetti, G., ..., Nechushtai, R.
• A VDAC1-mediated NEET protein chain transfers [2Fe-2S] clusters between the mitochondria and the cytosol and impacts mitochondrial dynamics, Proceedings of the National Academy of Sciences, 119, 7, 2022, Karmi, Ola, Henri-Baptiste Marjault, Fang Bai, Susmita Roy, Yang-Sung Sohn, Merav Darash Yahana, Faruck Morcos, et al.
• Cadmium interference with iron sensing reveals transcriptional programs sensitive and insensitive to reactive oxygen species, Journal of Experimental Botany, 73, 1, 2022, Samuel A McInturf, Mather A Khan, Arun Gokul, Norma A Castro-Guerrero, Ricarda Höhner, Jiamei Li, Henri-Baptiste Marjault, Yosef Fichman, Hans-Henning Kunz, Fiona L Goggin, Marshall Keyster, Rachel Nechushtai, Ron Mittler, David G Mendoza-Cózatl, 324-338
• The balancing act of NEET proteins: Iron, ROS, calcium and metabolism, Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 2020, Nechushtai, R., Karmi, O., Zuo, K., Marjault, H.B., Darash-Yahana, M., Sohn, Y.S., King, S.D., Zandalinas, S.I., Carloni, P., Mittler, R., 118805
• The two redox states of the human NEET proteins'[2Fe-2S] clusters, JBIC Journal of Biological Inorganic Chemistry, 26, 7, 2021, Zuo, K., Marjault, H. B., Bren, K. L., Rossetti, G., Nechushtai, R., & Carloni, P., 763-774
• A Combined Drug Treatment That Reduces Mitochondrial Iron and Reactive Oxygen Levels Recovers Insulin Secretion in NAF-1-Deficient Pancreatic Cells, Antioxidants, 10, 8, 2021, Ola Karmi, Henri-Baptiste Marjault, Luca Pesce, Paolo Carloni, Jose N. Onuchic, Patricia A. Jennings, Ron Mittler, Rachel Nechushtai, 1160
• Chemical targeting of NEET proteins reveals their function in mitochondrial morphodynamics, EMBO reports, 21, 12, 2020, Molino, D., Pila-Castellanos, I., Marjault, H.B., Dias Amoedo, N., Kopp, K., Rochin, L., Karmi, O., Sohn, Y.S., Lines, L., Hamaï, A., Joly, S., e49019 NEET proteins as novel drug targets for mitochondrial dysfunction, Clinical Bioenergetics, 2020, Marjault HB., Zuo K., Mittler R., Carloni P., Nechushtai R. Expression of a dominant-negative AtNEET-H89C protein disrupts iron-sulfur metabolism and iron homeostasis in Arabidopsis, The Plant Journal, 2019, Zandalinas, Sara I., Luhua Song, Soham Sengupta, Sam McInturf, DeAna G. Grant, Henri-Baptiste Marjault, Norma A. Castro-Guerrero, et al.
• The antiapoptotic proteins NAF-1 and iASPP interact to drive apoptosis in cancer cells, Chemical science, 10, 3, 2019, Iosub-Amir, Anat, Fang Bai, Yang-Sung Sohn, Luhua Song, Sagi Tamir, Henri-Baptiste Marjault, Guy Mayer, et al., 665-673
• The unique fold and lability of the [2Fe-2S] clusters of NEET proteins mediate their key functions in health and disease, J Biol Inorg Chem, 2018, Ola Karmi, Henri-Baptiste Marjault, Luca Pesce, Paolo Carloni, Jose N. Onuchic, Patricia A. Jennings, Ron Mittler, Rachel Nechushtai, https://doi.org/10.1007/s00775-018-1538-8
• Molecular Dynamics Simulations of the [2Fe2S] Cluster-Binding Domain of NEET Proteins Reveal Key Molecular Determinants That Induce Their Cluster Transfer/Release, J Phys Chem B, 121, 10648-10656, 2017, Luca Pesce, Vania Calandrini, Henri-baptiste Marjault, Colin H. Lipper, Gulia Rossetti, Ron Mittler, Patricia A. Jennings, Andreas Bauer, Rachel Nechushtai, Paolo Carloni
• Consequences of irradiation on adult spermatogenesis: Between infertility and hereditary risk, Mutation Research/Reviews in Mutation Research, 770, 340-348, 2016, Henri-Baptiste Marjault, & Allemand, I.